follow-ups of ten years or more) are somewhat limited. 2009) has demonstrated that a longer duration of untreated psychosis (DUP) is associated with a poorer outcome. - ISSN 1562-2975. Longer DUP has been associated with poorer prognosis (see the DUP and outcomes topic). Early intervention services are based on the premise that untreated psychosis may have a deleterious effect on outcome, particularly in the early years of illness. 45 Studies, primarily performed in high-income countries in which the duration of untreated psychosis is usually less than 5 years, have reported that a longer duration of untreated psychosis is associated with more severe positive and negative symptoms and lower rates of … The majority of the studies on duration of untreated psychosis have been conducted in developed countries; therefore this review focuses on publications from developing countries. It is unclear what determines duration of untreated psychosis (DUP) in schizophrenia and why long DUP predicts poor outcome. Early intervention in psychosis is a clinical approach to those experiencing symptoms of psychosis for the first time. The aim of this study was to evaluate the potential association between DUP and very long-term outcome (16-33 yrs) of schizophrenia by means of a retrospective design. D Arch Gen Psychiatry. Duration of untreated psychosis and clinical outcomes of first episode psychosis – an ... o only associated with the outcome through its effect on the exposure o not associated with known confounders of the exposure-outcome association (and assumedly unrelated to unknown confounders). Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. If so, outcome might be improved through earlier detection and treatment. Simantov R, Blinder E, Ratovitski T, et al. What is the duration of untreated psychosis (DUP)? The last 20 years have seen an increased focus on early intervention in psychotic disorders in research and clinical practice. In the psychiatry field, research allows the early identification of young people who are likely to be in the prodromal psychosis phase, which is also known Arch Gen Psychiatry 2005;62:975–83. It has been postulated that a longer DUP leads to a poorer prognosis. BACKGROUND Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Review: longer duration of untreated psychosis is associated with worse outcome in people with first episode psychosis Marshall M, Lewis S, Lockwood A, et al. There is fairly sound evidence that long duration of untreated psychosis and poor outcome are reliably correlated in the first year of psychosis (Marshall et al, 2005; Perkins et al, 2005) . Untreated psychosis has long been associated with worse clinical outcomes in patients with schizophrenia. Longer duration of untreated psychosis (DUP) prior to the initiation of treatment has been found to predict poorer short-term clinical and functional outcomes in patients with first-episode psychosis (FEP). The analyses revealed that a duration of untreated psychosis longer than 12 months was independently and significantly associated with a poorer outcome from first inpatient treatment. Untreated Psychosis Has Long-Term Impact on Memory September 10, ... Additionally, the length of DUP was directly predictive of symptom severity and outcome at three years. - 10:S1(2009). Duration of untreated psychosis: is it a criterion for outcome prediction? We examined the association between the duration of untreated psychosis and outcome for patients with delusional infestation. Second, a relationship of duration of untreated psychosis to outcome may indicate a neurodegenerative process and so have important implications for understanding the pathophysiology of schizophrenia. For schizophrenia and schizophreniform disorder, each increment in duration of untreated psychosis was associated with a 7.8 point decrease in global functioning and an increase in positive symptoms scores by 1.9 points. Duration of untreated psychosis predicts treatment outcome in an early psychosis program. Multi-episode patients had an earlier onset of the illness and a longer "duration of untreated psychosis" (DUP), defined as the interval between the onset of the first psychotic symptoms and the first antipsychotic treatment. This study examined outcome and factors related to it after one year of treatment of schizophrenia patients who were ill for many years and not previously treated. Altamura. . Duration of untreated psychosis (DUP), defined as delay in treatment with antipsychotic medication, was found to be associated with an unfavorable course of schizophrenia. 2014; 205 : 88-94 View in Article est association between DUP and outcome, which sup-ports the case for clinical trials that examine the effect of reducing DUP. DUP is generally determined as the time from the onset of psychotic symptoms to the initiation of treatment or first clinical presentation, when a diagnosis of first-episode psychosis may be given. Background: Studies performed to assess the relevance of duration of untreated psychosis (DUP) as a predictor of long-term outcome (i.e. Duration of untreated psychosis has a significant effect on treatment adherence in the initial recovery phase. Results : A longer duration of untreated psychosis was associated with a significantly poorer functional and symptomatic outcome 4 years later. A logistic regression analysis was performed to test a model for the possible predictors of the two different patterns of outcome. Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis. J. Psychiatry 162, 1785–1804. ables (duration of untreated psychosis, prodrome, gender, years in education, age at onset of psychotic symptoms, PSA1 score) and outcome dimensions using corre-lation analyses. Dopamine-induced apoptosis in human neuronal cells: inhibition by nucleic acids antisense to the dopamine transporter. ((Intervento presentato al 9. convegno 9th World Congress of Biological Psychiatry tenutosi a Paris, France nel 2009. Association between duration of untreated psychosis and in cohorts of first-episode outcome patients: a systematic review. RESULTS: A longer duration of untreated psychosis was associated with a significantly poorer functional and symptomatic outcome 4 years later. Delay in intensive psychosocial treatment (DIPT) may also be related to outcome. Perkins D.O., Gu H., Boteva K.Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and … The authors reviewed the literature on the association of duration of untreated psychosis with symptom severity at first treatment contact and with treatment outcomes and conducted a meta-analysis examining these relationships. Psychosis is one of the most debilitating psychiatric conditions with limited options to improve outcomes. This multi-centre international study included 211 consecutive patients. Abstract; Marshall M, Lewis S, Lockwood A, Drake R, Jones P, Croudace T. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: A … DOI: 10.1097/00001504-200304002-00007 Corpus ID: 147676606. Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear. - In: THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY. Interventions have typically aimed at either reducing the duration of untreated psychosis (DUP), or developing specialized treatment facilities for patients with first episode psychosis … Machine translation. Duration of untreated psychosis (DUP) is the time between onset of psychotic symptoms and initiation of antipsychotic medication. 2005;62:975-983 URATION OF UNTREATED psychosis (DUP) is de-fined as the time from manifestationofthefirst psychotic symptom to initiation of adequate antipsychotic drug treatment. It forms part of a new prevention paradigm for psychiatry and is leading to reform of mental health services, especially in the United Kingdom and Australia.. 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